Part I Wound Repair and Regeneration

Mechanisms of Vessel Regression: Toward an Understanding of the Resolution of Angiogenesis

Mateusz S. Wietecha, Wendy L. Cerny, Luisa A. DiPietro

Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals

Aiko Kawasumi, Natsume Sagawa, Shinichi Hayashi, Hitoshi Yokoyama, and Koji Tamura

Part II  Limb and Lens Regeneration

Cellular Plasticity During Vertebrate Appendage Regeneration

James R. Monaghan and Malcolm Maden

Cell Signaling Pathways in Vertebrate Lens Regeneration.

Jonathan J. Henry, Alvin G. Thomas, Paul W. Hamilton, Lisa Moore, and Kimberly J. Perry

Part III  Musculoskeletal Repair and Regeneration

Regenerative Medicine: Challenges and Perspectives for Successful Therapies

S. Viswanathan and C. Joshi

Employing the Biology of Successful Fracture Repair to Heal Critical Size Bone Defects

Jo Ann Cameron, Derek J Milner, Jung Seok Lee, Jianjun Cheng, Nicholas X Fang, and Iwona M Jasiuk

Muscle Repair and Regeneration:  Stem Cells, Scaffolds, and the Contributions of Skeletal Muscle to Amphibian Limb Regeneration.

Derek J Milner and Jo Ann Cameron.

Part IV  Neural Regeneration

Neural Regeneration

Melissa M. Steward, Akshayalakshmi Sridhar, and Jason S. Meyer

Teleost Fish as a Model System to Study Successful Regeneration of the Central Nervous System

Günther K.H. Zupanc and Ruxandra F. Sîrbulescu

Part V  Epigenetics and Cell Cycle in Regeneration

Epigenetics and Regeneration

Nobuyasu Maki and Hironobu Kimura

Cell Cycle Regulation and Regeneration

Ellen Heber-Katz, Yong Zhang, Khamila Bedelbaeva, Fengyu Song, Xiaoping Chen, and David L. Stocum

Regeneration, the homeostatic ability to maintain tissue structure in the face of normal cell turnover or loss of tissue damaged by trauma or disease, is an essential developmental process that continues throughout life. As recently as a decade ago, any serious discussion of the possibility of regeneration becoming a practical medical tool in the near future had the air of science fiction or over-optimistic speculation. The term "regenerative medicine" was certainly on many lips but few actually expected to soon see it applied in a clinical setting. A tidal wave of discovery has changed that and investigating the cellular mechanisms of natural regeneration has become one of the hottest topics in developmental biology and biomedicine in general. Many researchers entering the field find that the regeneration literature is still quite diffuse perhaps owing to the disparate biological systems that have been the object of study including hydra, planaria, newts, axolotls and more recently several mouse strains. The volume editors believe that an attempt to organize or systematize the literature is long overdue. In this volume, respected experts highlight the latest findings in vertebrate (including mammals) wound healing and regeneration. They present eleven reviews that cover a wide range of topics, from wound repair and its relationship to regeneration, through systems including lenticular, neural, and musculoskeletal tissues and limbs, to epigenetics and the role of the cell cycle. Nuclear reprogramming and cellular plasticity, which open the door for potential regenerative medical therapies for injury and degenerative disease, are recurring themes throughout the book. We are all now part of the regeneration revolution.