Advances in molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its therapeutic applications. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, this book examines rodent models for pain associated with bone cancer, osteoarthritis, and cardiac episodes. It covers the cloning of highly specific receptors and the analysis of modular molecular mechanisms relevant to painful neuropathies, while also considering the trend toward translational research in the commercial pharmaceutical industry.

Lawrence Kruger, Distinguished Professor of Neurobiology, University of California, USA

Alan Light, Research Professor of Anesthesiology, University of Utah, USA

Painful Multi-Symptom Disorders: A Systems Perspective. Neurotrophic Factors and Nociceptor Sensitization. The Role of Visceral Afferents in Disease. Cancer Pain: From the Development of Mouse Models to Human Clinical Trials. Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States. Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes. Transgenic Mouse Models for the Tracing of "Pain" Pathways. Cytokines in Pain. Glial Modulation in Pain States: Translation into Humans. On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain. Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes. Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents. Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection? What Can Neuroimaging Tell Us about Central Pain? Human Brain Imaging Studies of Chronic Pain: Translational Opportunities. Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs. Large Animal Models for Pain Therapeutic Development. Drug Discovery and Development for Pain. Index.