This accessible guide to obesity and its clinical management provides clear, didactic, clinically focused guidance for all healthcare professionals involved in the treatment and management of patients with obesity, thus acting as a repository of essential practical knowledge. It is an ideal practical guide for registrars and residents in endocrinology and metabolic disease, as well as all other health professionals who regularly manage obese patients, such as specialist obesity and diabetes nurses, dietitians, and general practitioners with an interest in obesity management.

Preface vii

Part 1 The Biology of Obesity-Why It Occurs 1
Victor Lawrence, Section Editor

1 Energy Balance and Body Weight Homeostasis 3

2 The Genetic Basis of Obesity 13

3 Adipocyte Biology 25

4 Fetal and Infant Origins of Obesity 33

5 Metabolic Fuels and Obesity 41

Part 2 Clinical Management of the Obese Individual 51
Robert Kushner, Section Editor

6 Practical Guide to Clinical Assessment and Treatment Planning 53

7 Stages of Obesity and Weight Maintenanc 63

8 Dietary Management 71

9 Physical Activity and Exercise 81

10 Behavior Therapy 91

11 Pharmacotherapy 99

12 Surgery 109

Part 3 Clinical Management of Obesity-Related Co-morbidities 121
Sudhesh Kumar and Milan K. Piya, Section Editors

13 Diabetes and Metabolic Diseases 123

14 Obesity and Reproductive Health 133

15 Gastro-intestinal and Hepatobiliary Disease 141

16 Respiratory Disease 149

17 Obesity and Cardiovascular Disease 157

18 Obesity: Mental Health and Social Consequences 167

19 Obesity and Musculo-skeletal Disease 175

20 The Obese Patient in Hospital 181

Conversion Table 187

Index 189

Robert Kushner, Professor of Medicine, Northwestern University Feinberg
School of Medicine, Chicago, USA

Victor Lawrence, Consultant Physician, Endocrinology and Diabetes,
St Mary's Hospital, Newport, Isle of Wight, UK

Sudhesh Kumar, Professor of Medicine, Warwick Medical School,
University of Warwick, UK