This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.

Dr. Junjie Xiao is the Vice Dean of the School of Life Science and also of the Medical School at Shanghai University. He is the Associate Editor of the Journal of Cardiovascular Translational Research, BMC Sports and Science, Medicine& Rehabilitation, and a member of the editorial board of BMC Medicine. He is the author or co-author of numerous scientific articles in various journals, including Cell Metabolism, Nature Communications, Annual Review of Genomics and Human Genetics, Circulation, and Theranostics. His major research interest is exercise and myocardial protection, especially using exercise as a platform to identify novel targets for enhancing cardiac regeneration and combating heart failure.

An overview of genome editing in cardiovascular and metabolic diseases.- Bioinformatics research methodology of genome editing in cardiovascular and metabolic diseases.- Online databases of genome editing in cardiovascular and metabolic diseases.- Application of systems biology for genome editing involved in regulating of cardiovascular and metabolic diseases.- Bioinformatics for reducing off-targets in cardiovascular and metabolic diseases.- Genome editing and cardiac regeneration.- Genome editing and myocardial development.- Genome editing and heart failure.- Genome editing and pathological cardiac hypertrophy.- Genome editing and cardiac remodeling.- Genome editing and diabetic cardiomyopathy.- Genome editing and cardiac arrhythmias.- Genome editing and atrial fibrillation.- Genome editing and muscle atrophy.- Genome editing and obesity.- Genome editing and fatty liver.- Genome editing and diabetes.- Genome editing and gout.- Genome editing and protein energy malnutrition.- Genome therapy and cardiovascular diseases.- Therapeutics in metabolic diseases.- Gene editing and human iPSCs in cardiovascular and editing diseases.- Prospective advances in genome editing investigation.