There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.

Preface. 1. The molecular aspects of Tight junctions2. The distribution of tight junctions and junctional proteins in the body3. Methods to study Tight Junctions4. Enhanced vascular permeability in solid tumors: A promise for Anticancer Nanomedicine5.Tight junctions, Junctional Adhesion Molecules (JAMs), and the blood brain barrier.6. Tight Junctions in human urinary bladder cancer7. Tight junctions in colorectal cancer8. Tight Junctions in breast cancer: multifaceted players in tumorigenesis and progression9.Regulation of tight junctions for therapeutic advantages10.VEGF-Mediated Effects On Brain Microvascular Endothelial Tight Junctions and Transmigration of Breast Cancer Cells Across The Blood-Brain Barrier 11. Claudin-5 and cancer metastasis12. Signaling pathways regulating endothelial cell-cell junctions as a barrier to tumor cell metastasis13. The ROCK signalling pathway and Tight JunctionsIndex.