Neuroectodermal Tumor Versus Ewing's Sarcoma - Immunohistochemical and Electron Microscopic Observations.- Immunohistological Demonstration of Osteonectin in Normal Bone Tissue and in Bone Tumors.- Tumor Bone Formation in Different Osteosarcomas: Topological, Bioehemical, and Histochemical Analyses.- The Proliferation Behavior of Bone Tumors Investigated with the Monoclonal Antibody Ki-67.- Flow Cytometric DNA Analysis of Bone Tumors.- Steroid Receptors and Giant Cell Tumor of Bone.- Chondroid Chordoma: A Low-Grade Chondrosarcoma and Its Differential Diagnosis.- Immunohistochemical Investigation of Chordomas: Histogenetic and Differential Diagnostic Aspects.- The Cytogenesis of Macrophages and Osteoclast-like Giant Cells in Bone Tumors with Special Emphasis on the So-Called Fibrohistiocytic Tumors.- Indexed in ISR.

During the past few years, a considerable number of monographs on bone tumors have been published. They are mainly restricted to bone tumors as clinical-pathological entities, since their diagnosis, more than that of other tumors, requires the interdisciplinary cooperation between orthopedic specialist, radiologist, and pathologist. However, investiga­ tions concerning the histogenesis of bone tumors are rather limited, although they might be helpful in explaining the unique morphological heterogeneity of tumors of the skeletal system. Furthermore, the histo­ genetic approach in the study of bone tumors may facilitate the inter­ pretation of the advanced cytobiological methods available for improv­ ing classification and diagnosis. Therefore, this volume presents recent pathological advances in the biological characterization of bone tumors. A major chapter deals with the differential diagnosis of Ewing's sarcoma as regards its demarcation from the so-called neuroectodermal tumor of bone. The analysis of the ground substances in bone-forming tumors may be helpful for their classification. Therefore the volume includes a chapter on the biochemical and histochemical analysis of different osteosarcoma types. Recently it has become clear that in addition to different collagen types which are not specific for bone tissue, several bone-specific proteins occur, one of which is osteonectin. Its distribu­ tion is obviously important for the classification and diagnosis of osteo­ blastic tumors. Proliferative behavior is of major importance for the diagnosis of malignant tumors.