In this issue of Current Topics in Microbiology and Immunology the authors present a unique range of examples of the regenerative response and the role of stem cells from the amphibian to human. It seems that all roads lead to cells that have the plasticity to become something else, not only in the amphibian but also in the mammal.

Amphibian Regeneration and Stem Cells.- Existence of Reserve Quiescent Stem Cells in Adults, From Amphibians to Humans.- Genetic Regulation of Mouse Stem Cells: Identification of Two Keratinocyte Stem Cell Regulatory Loci.- Myocardial Tissue Engineering and Regeneration as a Therapeutic Alternative to Transplantation.- Spallanzani's Mouse: A Model of Restoration and Regeneration.- 191.