General Outlook and Possibilities.- Literature-Based Discovery? The Very Idea.- The Place of Literature-Based Discovery in Contemporary Scientific Practice.- The Tip of the Iceberg: The Quest for Innovation at the Base of the Pyramid.- The 'Open Discovery' Challenge.- Where is the Discovery in Literature-Based Discovery?.- Methodology and Applications.- Analyzing LBD Methods using a General Framework.- Evaluation of Literature-Based Discovery Systems.- Factor Analytic Approach to Transitive Text Mining using Medline Descriptors.- Literature-Based Knowledge Discovery using Natural Language Processing.- Information Retrieval in Literature-Based Discovery.- Biomedical Application of Knowledge Discovery.

Contemporary Scienti?c Practice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 NeilR. SmalheiserandVetleI. Torvik The Tip of the Iceberg: The Quest for Innovation at the Base of the Pyramid. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 M. D. GordonandN. F. Awad The 'Open Discovery' Challenge. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 JonathanD. Wren Where is the Discovery in Literature-Based Discovery?. . . . . . . . . . . . . . . . 57 R. N. Kostoff Part II Methodology and Applications Analyzing LBD Methods using a General Framework. . . . . . . . . . . . . . . . . 75 A. K. Sehgal,X. Y. Qiu,andP. Srinivasan Evaluation of Literature-Based Discovery Systems. . . . . . . . . . . . . . . . . . . . 101 M. Yetisgen-YildizandW. Pratt vii viii Contents Factor Analytic Approach to Transitive Text Mining using Medline Descriptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115 J. StegmannandG. Grohmann Literature-Based Knowledge Discovery using Natural Language Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 D. Hristovski,C. Friedman,T. C. Rind?esch,andB. Peterlin Information Retrieval in Literature-Based Discovery. . . . . . . . . . . . . . . . . . 153 W. Hersh Biomedical Application of Knowledge Discovery . . . . . . . . . . . . . . . . . . . . . 173 A. Koike Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 Contributors NeveenFaragAwad SchoolofBusiness,WayneStateUniversity,USA CarolFriedman DepartmentofBiomedicalInformatics,ColumbiaUniversity,622West168St, NewYork,NY10032,USA MichaelD. Gordon RossSchoolofBusiness,UniversityofMichigan,USA mdgordon@umich. edu GuenterGrohmann Charite-Institute ¿ ofMedicalInformatics,12203Berlin,Germany guenter. grohmann@charite. de WilliamHersh DepartmentofMedicalInformaticsandClinicalEpidemiology, SchoolofMedicine,OregonHealthandScienceUniversity, 3181SWSamJacksonParkRd. ,Portland,OR97239,USA hersh@ohsu. edu DimitarHristovski InstituteofBiomedicalInformatics,MedicalFaculty,UniversityofLjubljana, Vrazovtrg2/2,1104Ljubljana,Slovenia dimitar. hristovski@mf. uni-lj. si AsakoKoike CentralResearchLaboratory,HitachiLtd.