Valerie I. Brown, MD, PhD

Director, Experimental Therapeutics, Pediatric Hematology/Oncology

Director, Pediatric Hematology/Oncology Fellowship Program

Penn State Milton S. Hershey Medical Center and Children's Hospital, Division of Pediatric Oncology/Hematology, Hershey, PA, USA

This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader.

Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.

Introduction.- Historical Overview of Pediatric HSCT.- Brief Introduction to the Basic Scientific Principles of Hematopoietic Stem Cell Transplantation (HSCT).- Pretransplantation: Indications and Timing.- Spotlight on Minimal Residual Disease (MRD): Impact of MRD on HSCT Outcomes for Pediatric Leukemia.- HSCT Recipient Pretransplantation Evaluation.- How to Select a Donor and Hematopoietic Stem Cell Source: Related versus Unrelated Donors for Allogeneic HSCT.- Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement and Manipulation.- Preparing the Patient for HSCT: Conditioning Regimens and their Scientific Rationale.- Engraftment and Chimerism.- Graft Failure.- Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome.- Nutrition in the Peri-HSCT Period.- Mucositis and Pain in the Peri- HSCT Period.- Hepatoxicity in the Peri- HSCT Period.- Renal Toxicities in the Peri-HSCT Period.- Infectious Complications and HSCT.- Acute Graft-Versus-Host Disease: Diagnosis, Prophylaxis, and Treatment.- Chronic GVHD.- Hematologic Complications Associated with HSCT.- Pulmonary Complications Associated with HSCT.- Renal Complications Associated with HSCT.- Cardiac Complications Associated with HSCT.- Neurologic and Sensory Complications Associated with HSCT.- HSCT-Associated Complications of the Skin, Hair and Nails.- Immune Reconstitution after Hematopoietic Stem Cell Transplantation.- Life After HSCT: Survivorship and Long-Term Issues.- Medications commonly Used in Pediatric HSCT.