A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.

Part I. Introduction

Chapter 1. Ventricular Repolarization and the Identification of the Sudden Death Candidate: Hype or Hope?
Hein J. Wellens and Douglas P. Zipes

Chapter 2. Historical Milestones of Electrical Signal Recording and Analysis
Thorsten Lewalter and Berndt Luderitz

Part II. Basic Electrophysiology, Pharmacology, and Molecular Biology of Ventricular Repolarization
Edited by Charles Antzelevitch

Chapter 3. Physiology and Molecular Biology of Ion Channels Contributing to Ventricular Repolarization
Jeanne M. Nerbonne and Robert S. Kass

Chapter 4. Electrophysiology and Pharmacology of Ventricular Repolarization
Charles Antzelevitch, Andrew C. Zygmunt, and Robert Dumaine

Chapter 5. How Do We Measure Repolarization inside the Heart?
Charles Antzelevitch, Andrew C. Zygmunt, Jeffrey Fish, Guillermo Perez, and Fabiana Scornik

Chapter 6. Contribution of Electrical Heterogeneity of Repolarization to the ECG
Charles Antzelevitch and Vladislav V. Nesterenko

Chapter 7. Electrical and Structural Remodeling of the Ventricular Myocardium in Disease
Antonis A. Armoundas and Gordon F. Tomaselli

Chapter 8. Ischemia-Related Changes in Repolarization
André G. Kléber and Michiel J. Janse

Chapter 9. The Long QT Syndrome: Molecular and Genetic Aspects
Carlo Napolitano and Silvia G. Priori

Chapter 10. Ion Channel Disease as a Cause of the Brugada Syndrome: Molecular and Genetic Aspects
Connie R. Bezzina and Arthur A. M. Wilde

Chapter 11. Cellular and Ionic Mechanisms Underlying Arrhythmogenesis
Charles Antzelevitch, Alexander Burashnikov, and Jose Di Diego

Part III. Clinical Physiology and Pathophysiology of Ventricular Repolarization: Theory and Practice
Edited by Steven C. Hammill, Win K-Kuang Shen, and Ihor Gussak

Chapter12. Evaluation of VentricularRepolarization: The Clinician's Perspective
Jan Nemec, Steven C. Hammill, and Win-Kuang Shen

Chapter 13. Human Cardiac Repolarization
Philip T. Sager

Chapter 14. QT interval and Its Drug-Induced Prolongation
Wojciech Zareba and Arthur J. Moss

Chapter 15. Neuro-Mediated Repolarization Abnormalities
Philippe Coumel and Pierre Maison-Blanche

Chapter 16. The Electrophysiologic Matrix: Equilibrium and Arnsdorf's Paradox
Morton F. Arnsdorf

Chapter 17. Antiarrhythmic Drugs and Future Direction
Arshad Jahangir, Andre Terzic, and Win-Kuan Shen

Part IV. Specific Electrocardiographic Phenomena and Clinical Syndromes of Ventricular Repolarization
Edited by Ihor Gussak, Charles Antzelevitch, and Preben Bjerregaard

Chapter 18. ECG Phenomena of the Early Ventricular Repolarization: Early Repolarization Syndrome
Ihor Gussak, Charles Antzelevitch, and Preben Bjerregaard

Chapter 19. The Brugada Syndrome
Pedro Brugada, Ramon Brugada, Charles Antzelevitch, Koonlawee Nademanee, Jeffrey Towbin, and Josep Brugada

Chapter 20. Clinical Evaluation, Risk Stratification, and Management of Congenital Long QT Syndrome
Anant Khositseth and Michael J. Ackerman

Chapter 21. Prolonged Repolarization and Sudden Infant Death Syndrome
Peter J. Schwartz

Chapter 22. Short QT Interval: ECG Phenomenon and Clinical Syndrome, Ihor Gussak, Charles Antzelevitch
Daniel Goodman, and Preben Bjerregaard

Chapter 23. T-Wave Alterans: Mechanisms, Relevance, and Clinical Implications
Etienne Pruvot and David S. Rosenbaum. Index.