1. Multicenter Clinical Sample Collection for Microarray Analysis
Tony S. Mondala, Daniel R. Salomon, and Steven R. Head
2. Selective Isolation of Total RNA from Mouse Melanoma Subsets Using Fluorescence Activated Cell Sorting
Scott Tighe and Matthew A. Held
3. Microarray Analysis of Embryonic Stem Cells and Differentiated Embryoid Bodies
Alexander C. Zambon and Christopher S. Barker
4. Determination of Alternate Splicing Events Using the Affymetrix Exon 1.0 ST Arrays
Sita Subbaram, Marcy Kuentzel, David Frank, C. Michael DiPersio, and Sridar V. Chittur
5. Profiling microRNA Expression with the Illumina BeadChip Platform
Julissa Tsao, Patrick Yau, and Neil Winegarden
6. TaqMan® Array Cards in Pharmaceutical Research
David N. Keys, Janice K. Au-Young, and Richard A. Fekete
7. DMET¿ Microarray Technology for Pharmacogenomics-Based Personalized Medicine
James K. Burmester, Marina Sedova, Michael H. Shapero, and Elaine Mansfield
8. The Use of Microarray Technology for Cytogenetics
Bassem A. Bejjani, Lisa G. Shaffer, and Blake C. Ballif
9. PCR/LDR/Universal Array Platforms for the Diagnosis of Infectious Disease
Maneesh Pingle, Mark Rundell, Sanchita Das, Linnie M. Golightly, and Francis Barany
10. RIP-CHIP in Drug Development
Ritu Jain, Francis Doyle, Ajish D. George, Marcy Kuentzel, David Frank, Sridar V. Chittur, and Scott A. Tenenbaum
11. ChIPing Away At Global Transcriptional Regulation
Kelly Jackson, James Paris, and Mark Takahashi
12. HELP (HpaII Tiny Fragment Enrichment by Ligation-Mediated PCR) Assay for DNA Methylation Profiling of Primary Normal and Malignant B Lymphocytes
Rita Shaknovich, Maria E. Figueroa, and Ari Melnick
13. High-Throughput Screening of Metalloproteases Using SmallMolecule Microarrays
Mahesh Uttamchandani
14. Metabolic Enzyme Microarray Coupled with Miniaturized Cell-Culture Array Technology for High-Throughput Toxicity Screening
Moo-Yeal Lee, Jonathan S. Dordick, and Douglas S. Clark
15. Use of Tissue Microarray to Facilitate Oncology Research
Panagiotis Gouveris, Paul M. Weinberger, and Amanda Psyrri
16. Small Molecule Selectivity and Specificity Profiling Using Functional Protein Microarrays
Peter R. Kraus, Lihao Meng, and Lisa Freeman-Cook
17. Production and Application of Glycan Microarrays
Julia Busch, Ryan McBride, and Steven R. Head

While the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital applications. Covering the field of drug discovery through its various aspects, including high throughput screening, target identification, drug metabolism and toxicity screening as well as clinical sample handling, this volume also addresses new emerging fields like miRNA profiling, ribonomic and glycomic profiling. All chapters, contributed by experts in the field, follow the highly successful Methods in Molecular Biology(TM)series format, which is comprised of brief introductions, lists of required materials and reagents, readily reproducible, step-by-step lab protocols, along with detailed tips on troubleshooting and avoiding known pitfalls, making this book an easy read for investigators at all levels of expertise.

Authoritative and cutting-edge, Microarray Methods for Drug Discovery provides an ideal desk reference for scientists who wish to use microarray technology in order to better understand a variety of biological interactions in their respective fields.