Advances in Lipid Research, Volume 19 is a seven-chapter text that covers the physical and biological aspects of lipid metabolism.
The first chapter deals with the interactions between circulating lipids and lipid proteins and the arterial tissue matrix. The subsequent chapter discusses the apolipoprotein C metabolism, the roles of lecithin-cholesterol acyltransferase and cholesterol ester transfer protein in intravascular cholesterol transport. Other chapters explore the significance of bile acid biosynthesis for cholesterol homeostasis, the metabolism of phosphatidylserine, and gas chromatographic and mass spectrometry analysis of prostanoids. The last chapter considers the role of dietary fiber in health and disease.
This book is of great value to lipid and enzyme chemists, biochemists, and researchers.
List of ContributorsPrefaceThe Interaction of Lipids and Lipoproteins with the Intercellular Matrix of Arterial Tissue: Its Possible Role in Atherogenesis I. Introduction II. Collagen III. Elastin IV. Glycosaminoglycans and Proteoglycans V. The Interactions of Glycoproteins of the Arterial Extracellular Matrix with Lipids and Lipoproteins VI. The Possible Effect of the Extracellular Matrix on Lipoprotein Movement through the Arterial Intima-Media VII. Conclusion ReferencesApolipoprotein C Metabolism in Man I. Introduction II. Methodology III. Structure-Function Relationships IV. Metabolism of C Apolipoproteins V. Measurements of C Apolipoprotein Kinetics in Man ReferencesLecithin: Cholesterol Acyltransferase and Intravascular Cholesterol Transport I. Introduction II. LCATase Characterization III. LCATase Reaction with Plasma Lipoproteins IV. Cholesteryl Ester Transfer Protein V. LCATase and Cellular Cholesterol Homeostasis VI. LCATase, Cholesteryl Ester Transfer Protein, and Intravascular Cholesterol Transport: Conclusions ReferencesDevelopment of Bile Acid Biogenesis and Its Significance in Cholesterol Homeostasis I. Introduction II. Development of Bile Acid Pool in Animals and Man III. Cholesterol and Bile Acid Metabolism in Fetal and Neonatal Liver IV. The Significance of Bile Acids and Sterols in Meconium V. Role of Endocrine Factors in the Development of Bile Acid Biogenesis VI. Stimulation of Bile Acid Biogenesis During Development as a Means of Improving Cholesterol Handling in Adult Life VII. Conclusions ReferencesBiosynthesis and Transport of Phosphatidylserine in the Cell I. Introduction II. Net Synthesis of Phosphatidylserine III. Base Exchange Reaction IV. ATP-Dependent Phosphatidylserine Formation V. Decarboxylation of Phosphatidylserine VI. Transport of Phosphatidylserine VII. Conclusions ReferencesAnalysis of Prostanoids by GC/MS Measurement I. Introduction II. Gas Chromatography III. Mass Spectrometry IV. Derivatization of Prostanoids for GC/MS Measurement V. Computer Technology for GC/MS Measurements VI. Characteristics of GC/MS and RIA Analysis VII. Summary ReferencesMorphological Aspects of Dietary Fibers in the Intestine I. Introduction II. Materials and Methods III. Results IV. Discussion ReferencesAuthor IndexSubject IndexContents of Previous Volumes