A comprehensive review of current tactics in the therapeutic management of Parkinson's disease, this volume offers summaries of salient research findings as well as contemporary attitudes and practical advice from field specialists. The well-timed Third Edition is expanded and topically reorganized to register trends and progress in anti-parkinsonian medications, ablative surgical options, deep brain stimulation, nonmotor symptom treatments, nonmedical strategies, and investigational therapies.

Background: early iconography of Parkinson's disease, Christopher G. Goetz. Clinical aspects: epidemiology of Parkinsonism, Ali H. Rajput, Alex Rajput, and Michele Rajput; differential diagnosis of Parkinsonism, Kapil D. Sethi; pathophysiology and clinical assessment of Parkinsonian symptoms and signs, Joseph Jankovic; nonmotor symptoms of Parkinson's disease, Richard B. Dewey, Jr; neuropsychological aspects of Parkinson's disease and Parkinsonian syndromes, Alexander I. Troster and Steven Paul Woods; treatment of mental changes, Jorge Juncos; neuroimaging in Parkinson's disease, Kenneth Marek, Danna Jennings, and John Seibyl. Pathology and neurochemistry: neuropathology of Parkinsonism, Dennis W. Dickson; neurochemistry, Jayaraman Rao; neurophysiology/circuitry, Erwin Montgomery; animal models of Parkinson's disease and related disorders, Giselle M. Petzinger and Michael W. Jakowec; dopamine receptor diversity - anatomy, function, and relevance to Parkinson's Disease, Deborah C. Mash. Aetiology: genetics, Zbigniew K. Wszolek and Matthew Farrer; environmental risk factors for Parkinson's disease, Jay M. Gorell and Benjamin A. Rybicki. Medications: amantadine and anticholinergics, Joseph S. Chung, Allan D. Wu, and Mark D. Lew; levodopa, Anthony J. Santiago and Stewart A. Factor; dopamine agonists, Mark A. Stacy; monoamine oxidase inhibitors in Parkinson's disease, Daryl Victor and Cheryl Waters; catechol-o methyltransferase in Parkinson's disease, Ronald F. Pfeiffer; investigational pharmacological treatments for Parkinson's disease, William Ondo. Surgical therapy: lesion surgeries, Michael Samuel and Anthony E. Lang; deep brain stimulation in Parkinson's disease, Rajesh Pahwa and Kelly E. Lyons; neural transplantation in Parkinson's disease, Elmyra V. Encarcion and Robert A. Hauser. Other forms of treatment: Parkinson's disease symptom management - an interdisciplinary approach, Ruth A. Hagestuen, Rosemary L. Wichmann, and Marjorie L. Johnson.

Rajesh Pahwa, University of Kansas Medical Center, Kansas City. Kelly E. Lyons, Ph.D University of Kansas Medical Center. William Koller