Cancer in pregnancy presents physicians and their patients with a major dilemma. The urge to use the highest tolerable doses of chemotherapy, high doses of irradiation and surgery, has to be weighed carefully against their risks to the unborn baby. This book is the very first to attempt to quantify these risks, and to provide physicians with a core of knowledge that will be very relevant to making sound clinical decisions in the face of sometimes conflicting interests.

Preface G. Koren, M. Lishner and D. Farine; Introduction; 1. Cancer in pregnancy: Identification of unanswered questions on maternal and fetal risks G. Koren, L. Weiner, M. Lishner, D. Zemelickis and J Finnegan; 2. The pregnant patient with malignant disease - maternal fetal conflict D. Farine and E. N. Kelly; 3. Changes in drug disposition during pregnancy and its clinical implications G. Koren; 4. The role of the placenta in biotransformation of carcinogenic compounds L. Derewlany and G. Koren; 5. Antepartum fetal monotoring in the oncologic patient Y. Ezra and K. Panter; 6. The Toronto Study Group - Methodological Notes; 7. Motherisk - The process of counselling in reproductive toxicology G. Koren and A. Pastuszak; Specific Tumors During Pregnancy: 8. Maternal and fetal outcome following breast cancer in pregnancy D. Zemlickis, M. Lishner, P. Degendorfer, T. Panzarella, B. Burke, S. B. Sutcliffe and G. Koren; 9. Maternal and fetal outcome following Hodgkin's disease in pregnancy M. Lishner, D. Zemlickis, P. Degendorfer, T. Panzarella, S. B. Sutcliffe and G. Koren; 10. Non-Hodgkin's lymphoma and pregnancy D. Zemlickis, M. Lishner, S. B. Sutcliffe and G. Koren; 11. Maternal and fetal outcome following invasive cervical cancer in pregnancy M. Lishner, D. Zemlickis, P. Degendorfer, T. Panzarella, S. B. Sutcliffe and G. Koren; 12. Pregnancy and ovarian cancer M. Lishner and G. Koren; 13. Malignant melanoma and pregnancy M. Ravid and M. Lishner; 14. Leukemia during pregnancy M. Lishner; Fetal Effects of Cancer and its Treatment: 15. Prenatal irradiation and cancer Y. Bentur; 16. Review of fetal effects of cancer chemotherapeutic agents D. Zemlickis, M. Lishner and G. Koren; 17. Fetal outcome folowing in utero exposure to cancer chemotherapy - The Toronto study D. Zemlickis, M. Lishner, P. Degendorfer, T. Panzarella, S. B. Sutcliffe and G. Koren; 18. Intrauterine causes of tumors in later life G. Koren; 19. Fetal tumors P. McParland; Index.