The first basic overview of all aspects of transplantation with a clarity not to be found in more inaccessible textbooks.
This brand new title provides a succinct overview of both the scientific and clinical principles of organ transplantation and the types of organ transplant, featuring highly-illustrated information covering core topics in transplantation including:
* Organ donors
* Organ preservation
* Assessment of transplant recipients
* Indications for transplantation
* Immunology of transplantation
* Immunosuppression and its complications
* Overviews of thoracic and abdominal organ transplantation, including the kidneys, liver, heart and lungs
Transplantation at a Glance is the ideal introduction for medical students, junior doctors, surgical trainees, immunology students, pharmacists, and nurses on transplant wards.
Preface 7
List of abbreviations 8
1 History of transplantation 10
Organ donors
2 Diagnosis of death and its physiology 12
3 Deceased organ donation 14
4 Live donor kidney transplantation 16
5 Live donor liver transplantation 18
Organ preservation
6 Organ preservation 20
Immunology of organ transplantation
7 Innate immunity 22
8 Adaptive immunity and antigen presentation 24
9 Humoral and cellular immunity 26
Histocompatibility in transplantation
10 Tissue typing and HLA matching 28
11 Detecting HLA antibodies 30
12 Antibody-incompatible transplantation 32
Organ allocation
13 Organ allocation 34
Immunosuppression
14 Immunosuppression: induction vs maintenance 36
15 Biological agents 37
16 T cell-targeted immunosuppression 38
Complications of immunosuppression
17 Side effects of immunosuppressive agents 40
18 Post-transplant infection 42
19 CMV infection 44
20 Post-transplant malignancy 46
Kidney transplantation
21 End-stage renal failure 48
22 Complications of ESRF 50
23 Dialysis and its complications 52
24 Assessment for kidney transplantion 54
25 Kidney transplantation: the operation 56
26 Surgical complications of kidney transplantation 58
27 Delayed graft function 60
28 Transplant rejection 62
29 Chronic renal allograft dysfunction 64
Pancreas and islet transplantation
30 Transplantation for diabetes mellitus 66
31 Pancreas transplantation 68
32 Islet transplantation 70
Liver transplantation
33 Causes of liver failure 72
34 Assessment for liver transplantation 74
35 Liver transplantation: the operation 76
36 Complications of liver transplantation 78
Intestinal transplantation
37 Intestinal failure and assessment 80
38 Intestinal transplantation 82
Heart transplantation
39 Assessment for heart transplantation 84
40 Heart transplantation: the operation 86
41 Complications of heart transplantation 88
Lung transplantation
42 Assessment for lung transplantation 90
43 Lung transplantation: the operation 92
44 Complications of lung transplantation 94
Composite tissue transplantation
45 Composite tissue transplantation 96
Xenotransplantation
46 Xenotransplantation 98
Index 100
Preface 7
List of abbreviations 8
1 History of transplantation 10
Organ donors
2 Diagnosis of death and its physiology 12
3 Deceased organ donation 14
4 Live donor kidney transplantation 16
5 Live donor liver transplantation 18
Organ preservation
6 Organ preservation 20
Immunology of organ transplantation
7 Innate immunity 22
8 Adaptive immunity and antigen presentation 24
9 Humoral and cellular immunity 26
Histocompatibility in transplantation
10 Tissue typing and HLA matching 28
11 Detecting HLA antibodies 30
12 Antibody-incompatible transplantation 32
Organ allocation
13 Organ allocation 34
Immunosuppression
14 Immunosuppression: induction vs maintenance 36
15 Biological agents 37
16 T cell-targeted immunosuppression 38
Complications of immunosuppression
17 Side effects of immunosuppressive agents 40
18 Post-transplant infection 42
19 CMV infection 44
20 Post-transplant malignancy 46
Kidney transplantation
21 End-stage renal failure 48
22 Complications of ESRF 50
23 Dialysis and its complications 52
24 Assessment for kidney transplantion 54
25 Kidney transplantation: the operation 56
26 Surgical complications of kidney transplantation 58
27 Delayed graft function 60
28 Transplant rejection 62
29 Chronic renal allograft dysfunction 64
Pancreas and islet transplantation
30 Transplantation for diabetes mellitus 66
31 Pancreas transplantation 68
32 Islet transplantation 70
Liver transplantation
33 Causes of liver failure 72
34 Assessment for liver transplantation 74
35 Liver transplantation: the operation 76
36 Complications of liver transplantation 78
Intestinal transplantation
37 Intestinal failure and assessment 80
38 Intestinal transplantation 82
Heart transplantation
39 Assessment for heart transplantation 84
40 Heart transplantation: the operation 86
41 Complications of heart transplantation 88
Lung transplantation
42 Assessment for lung transplantation 90
43 Lung transplantation: the operation 92
44 Complications of lung transplantation 94
Composite tissue transplantation
45 Composite tissue transplantation 96
Xenotransplantation
46 Xenotransplantation 98
Index 100
Menna Clatworthy is at the University of Cambridge and Addenbrooke's Hospital.
Christopher Watson is at the School of Clinical Medicine, University of Cambridge.
Michael Allison is at Cambridge University Hospitals NHS Foundation Trust.
John Dark is Professor of Cardiothoracic Surgery at the Regional Cardiothoracic Centre, The Freeman Hospital, Newcastle upon Tyne.