An authoritative review of the latest developments in thechemical biology of enzymes
In the first decade of the twenty-first century, enzymes andtheir multiple applications have played a critical role in thediscovery and development of many new therapeutic agents.This bookis a coordinated compilation of research expertise and currentopinion uniquely focused on enzymes and their properties andapplications.
Compiled by editors with a combined pharmaceutical experience ofover sixty years, the text provides in-depth reviews of recentdevelopments in selective topics on biosynthesis, biocatalysis, andchemical biology of enzymes as it applies to drug discovery,development, and manufacture.
The first in a multi-part series on enzymes, this volumefeatures three sections:
* New Approaches to Find and Modify Enzymes describes the emergingfield of metagenomics, presents the practical applications ofdirected evolution to enzymes and pathways, and explores approachesfor the discovery and design of biocatalysts
* Biocatalytic Applications reviews specific applications ofdifferent reactions in producing active pharmaceutical ingredientsand surveys recent developments employing enzymes in organicsynthesis
* Biosynthetic Applications goes over successful drug discoveriesand developments by combinatorial biosynthesis and reviews theapplication of combinatorial biosynthesis among multiple compatiblehosts
These timely discussions, which cover everything from chemicalbiology of enzymes, to the redesign of binding and catalyticspecificities of enzymes, make this volume a valuable tool forkeeping up to date. As such, it is an important read forresearchers, students, and professors in the study ofbiotechnology, life sciences, biochemistry, enzymology, medicinalchemistry, and natural products.