1. Plant sources (species and geography) and components of Kratom
2. Historical uses
3. Recent patterns and reasons for use
4. Current legal and regulatory status
5. Chemistry (structures, properties, computer modeling)
6. Pharmacology (receptor binding, 2nd-messenger transduction, biased ligand)
7. Active metabolite (7-OHM)
8. Isolated tissue and in vivo studies (analgesia, constipation, etc.)
9. Pharmacokinetics (ADME)
10. TBD
11. TBD
12. TBD
13. Natural supplements and direct-to-consumer Kratom sales
14. IP on naturally occurring alkaloids
15. TBD
16. Drug-drug interactions
17. Susceptible populations
18. Purity and other quality control issues
19. Kratom entrepreneurship
20. Equity investment into the space
21. Medical marijuana as template for kratom

Kratom: History, Science and Therapeutic Potential is the first book to address the unregulated, widespread availability of kratom, with its weak opioid and stimulant effects, coupled with limited awareness of it by healthcare professionals. Kratom has great therapeutic utility and medicinal potential, but more study, caution, and possible regulation is needed. It discusses geographical sourcing, historical uses, current worldwide uses, and potential for treatment of other medical conditions. Most exciting for healthcare professionals will be the implications of this substance's potential for treatment of diseases like depression, ADHD, PTSD, and substance-use disorder, particularly opioid use disorder (OUD).
Moreover, kratom and its active alkaloid mitragynine are getting remarkable attention at federal and local governments as more than eight million Americans consume this product annually. Yet, the paucity of information for researchers and clinicians is troublesome.