This book provides background about the historical development of the state-of-the-art of research into drug action and drug abuse using planarians. It also provides insight into future possibilities for creative research into questions of other issues, such as learning and memory and regeneration.

1. Planaria: Short Introduction 2. Brain and Neural Networks 3. Gene Expression in the Brain and Central Nervous System in Planarians 4. Catecholamines in Planaria 5. Opioids in Planaria 6. Nitric Oxide in Lower Invertebrates 7. Second Messenger Systems in Planaria 8. Planaria as Model in Drug Abuse Research 9. Physical Dependence and Withdrawal in Planarians 10. Drug Combinations and Isoboles 11. Analysis of Behavior in the Planarian Model 12. The Planarian Regeneration Model as a Context for the Study of Drug Effects and Mechanisms