• Part I Clinical Description and Diagnosis


• 1: Conceptualizing Manic-Depressive Illness: The Bipolar-Unipolar Distinction and the Development of the Manic-Depressive Spectrum


• 2: Clinical Description


• 3: Diagnosis


• Part II Clinical Studies


• 4: Course and Outcome


• 5: Epidemiology


• 6: Children and Adolescents


• 7: Comorbidity


• 8: Suicide


• Part III Psychological Studies


• 9: Neuropsychology


• 10: Personality, Personality Disorders, and Interpersonal Functioning


• 11: Assessment


• 12: Creativity


• Part IV Pathophysiology


• 13: Genetics


• 14: Neurobiology


• 15: Neuroanatomy and Neuroimaging


• 16: Sleep and Circadian Rhythms


• Part V Treatment


• 17: Fundamentals of Treatment


• 18: Medical Treatment of Hypomania, Mania, and Mixed States


• 19: Medical Treatment of Depression


• 20: Maintenance Medical Treatment


• 21: Medication Adherence


• 22: Psychotherapy


• 23: Treatment of Children and Adolescents


• 24: Treatment of Comorbidity


• 25: Clinical Management of Suicide Risk

Originally published in 1990,Manic-Depressive Illness was the first book to comprehensively survey the massive body of clinical evidence on bipolar disorder collected over the past several decades, and to assess its meaning for both clinician and scientist. This long-awaited second edition of Manic-Depressive Illness will exhaustively review the biological and genetic literature that has dominated the field in recent years, and incorporate cutting-edge research conducted since publication of the first edition. The medical treatment of manic and depressive episodes is described, strategies for preventing future episodes are given in detail, and psychotherapeutic issues common in this illness are considered. This book, in its newly updated and expanded form, will be a valuable addition to the libraries of psychiatrists and other physicians, psychologists, clinical social workers, neuroscientists, pharmacologists, and the patients and families who live with manic-depressive illness.